Abd-Hafiz Al-Ghorafi, MokhtarMohammed Kamal, AliaaAbdullah, Jalal H.Ahmed Ali, TawfeekYassin, Shada H.2020-01-212020-01-2120192394-3211https://doi.org/https://www.ejpmr.com/admin/assets/downloads/1576321625.pdfStructure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3- cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic activity against MCF7 and HCT 116 cell lines.en-USThiophene Derivatives and Structure-based Drug designVEGFR-2AngiogenesisAnti-Cancer AgentsArticlehttps://doi.org/