Saleh, Sarah SObaydo, Reem HEl Hamd, Mohamed ARostom, YasminMohamed, DaliaLotfy, Hayam M2024-01-152024-01-152024-01https://doi.org/10.1016/j.microc.2024.109917http://repository.msa.edu.eg/xmlui/handle/123456789/5816In recent years, there has been a growing focus in analytical research on the ecological and sustainable aspects of analytical methodologies. However, it is necessary to apply the relevant metrics to evaluate the effectiveness of certain analytical methods. The present study aims to conduct a thorough analysis of the major turning points, merits, and demerits of some reported methods carried out to determine anti-viral drugs. Since the COVID-19 pandemic in 2020, researchers have become interested in antiviral drugs because it was the class of interest for facing the challenges of this pandemic. That’s why, a comprehensive application of several relevant green metrics has been reviewed. Additionally, the study intends to choose tools that have been reported as being green to use, explain the data that has been gathered, compare the data to one another, and highlight the benefits of particular features in each tool based on the timeline progress of using these tools. In addition, suggestions were made for adapting each tool to the recommended guidelines. Case studies were presented to highlight the proper application of each assessment tool.enSustainable; antiviral; COVID-19; green metrics; EVGArticlehttps://doi.org/10.1016/j.microc.2024.109917