Ahmed, Yara Hazem MohamedHelmy, Nour TarekMostafa, Mahdy MohammedShawki, Abodaba Besada2024-06-092024-06-092022Faculty Of Pharmacy Graduation Project 2020 - 2022http://repository.msa.edu.eg/xmlui/handle/123456789/6057Cancer is a huge group of diseases that is triggered almost in any organ of the body when irregular cells mature uncontrollably. Finding of a curative agent may be challenging. Recently, derivatives of Pyrazolopyrimidines have grabbed attention due to their structural variations and biological activities like anticancer, antimicrobial, anti inflammatory, antifungal, anti-acetylcholinesterase, and EGFR kinase inhibitors. Among them, pyrazolo [3,4-d] pyrimidine has become an interesting topic since it has a significant anticancer activity that will be targeted and focused on. Accordingly, our attention will concentrate on the efficiency of pyrazolo [3,4-d] pyrimidine as a novel anticancer drug. Furthermore, Hydrazide analogs have biological activities like antidepressants, anticonvulsants, anti-inflammatory, antibacterial, antimalarial, anticancer, and antimicrobial. We are aiming to design and synthesize a new derivative of Pyrazolopyrimidines, to get potential anti-cancer agents with minimization of adverse effects. Synthesis of the designed derivatives will be achieved according to the attached scheme followed by structure elucidation using spectroscopic methods (IR, 1HNMR, and 13C NMR). Derivatives are expected to have a low potential for causing side effects as they are derived from a naturally occurring antioxidant. Finally, the anti-cancer activity on cell lines will be evaluated.en-USOctober University For Modern Sciences and ArtsOctober University For Modern Sciences and Arts MSAMSAجامعة اكتوبر للعلوم الحديثة والادابPyrazolo-Pyrimidinesanti-microbialAnti-inflammatoryOther