EL-Khazragy, NashwaAbdel Aziz, Mahfouz AHesham, ManarMatbouly, SafaAbdallah Mostafa, SallyBakkar, AshrafAbouelnile, MariamNoufal, YassminMahran, Nievin AhmedAbdlkhalek, Marwa AliAbdelmaksoud, Mariam Fathy2021-10-292021-10-2910/26/2021https://doi.org/10.1016/j.imbio.2021.152149https://bit.ly/311nb6bT-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10-15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene expression were measured in peripheral blood (PB) samples of l85 children with T-ALL and forty non-leukemic samples as a control group. Cox regression analysis revealed that overexpression of LUNAR1, NOTCH1, and IGF-IR was significantly correlated with poor prognosis, short overall survival, and progression-free survival. We concluded that LUNAR1 could serve as an independent prognostic biomarker for T-ALL in children.en-USLong non-coding activator RNA (LUNAR1)Pediatric T-acute Lymphoblastic LeukemiaPrognostic biomarker.predictor biomarkerArticlehttps://doi.org/10.1016/j.imbio.2021.152149