Nadia M. HamdyMona G. El-SisiSherine M. IbrahimHeba ElNokoudyAhmad A. HadyGamal Eldein Fathy Abd-ellatefAl-Aliaa M. SallamBassant Mohamed Barakat2024-11-122024-11-122024-10-19Hamdy, N. M., El-Sisi, M. G., Ibrahim, S. M., ElNokoudy, H., Hady, A. A., Abd-Ellatef, G. E. F., Sallam, A. M., & Barakat, B. M. (2024). In silico Analysis and Comprehensive Review of Circular-RNA Regulatory Roles in Breast Diseases; a Step-Toward non-coding RNA Precision. Pathology - Research and Practice, 263, 155651. https://doi.org/10.1016/j.prp.2024.155651https://doi.org/10.1016/j.prp.2024.155651https://repository.msa.edu.eg/handle/123456789/6225In the current comprehensive review, we first highlighted circRNAs, which are key ncRNAs. Next, we discussed the relationships among circRNAs and breast cancer subtypes via in silico databases analysis and extensive literature search. CircRNAs, that sponge miRNA axes or act as silencers of oncogenic mRNAs, have been extensively addressed in the context of this review. During BC pathogenesis, the circRNA/microRNA/messenger RNA (mRNA) axis plays a major role in disease growth, progression, and survival/resistance and could be targeted for improved treatment options. This review also aimed to address oncogenic and tumor suppressor mRNAs, which are regulated by various circRNAs in BC. Moreover, we mentioned the relation of different circRNAs with cancer hallmarks, patient survival together with drug resistance. Additionally, we discussed circRNAs as vaccines and biomarkers in BC. Finally, we studied exosomal circRNAs as a hot interesting area in the research.enNc-epigeneticsCircular RNAs (circRNA)Breast cancer (BC)TNBCExosomesin silicoPrecision medicine (PM)Circular RNAs (circRNA)Breast cancer (BC)TNBCExosomesin silicoPrecision medicine (PM)Articlehttps://doi.org/10.1016/j.prp.2024.155651