Salman AlMarzouq, DouaaM Hilmy Elnagdi, Noha2019-11-062019-11-0620191420-3049https://doi.org/10.3390/molecules24091806https://cutt.ly/deTZGKKThe role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and pressure Q-tubes, is demonstrated. Novel aniline trimers are prepared using glycerol, and substituted anilines under pressure, in acidic medium and water. Glycerol was employed as a catalyst and a green solvent in the synthesis of novel pyridazines 13a-c. The mechanisms of the reactions and the catalytic effect of glycerol in protic and aprotic media are fully discussed. The structures of the synthesized compounds were determined via X-ray crystallography and spectroscopic methods.englycerolgreen chemistrymodified Skraup's quinoline synthesisreactions under pressureQ-tubes; polyanilineArticlehttps://doi.org/10.3390/molecules24091806