Abdelazem, Ahmed Z.Al-Sanea, Mohammad M.Park, Hyun-MeeLee, So Ha2019-12-052019-12-052016Cited References in Web of Science Core Collection: 170960-894Xhttps://doi.org/10.1016/j.bmcl.2016.01.014https://cutt.ly/Je8udA2Accession Number: WOS:000369377700041A new series of diarylamides, having a pyrimidinyl pyridine scaffold, was designed and synthesized. The target compounds were synthesized in three steps. A selected group from the target compounds was tested over a panel of 60 cancer cell lines at a single dose concentration of 10 mu M, and the most active compound, 5j, was further tested in a five-dose testing mode to determine its IC50 value over the 60 cell lines. In single-dose testing mode, compound 5j showed the highest growth inhibition against the NCI-60 cancer cell lines, while other tested compounds showed a weak to moderate inhibitory activity against a range of different cancer cell lines. In five-dose testing mode, compound 5j showed strong inhibitory activity in micro molar range against many cancer cell lines. Its major activity was against melanoma cancer cell lines. Therefore, compound 5j is a promising hit compound targeting this severe form of cancer. (C) 2016 Elsevier Ltd. All rights reserved.enSynthesisAnti-proliferative effectPyrimidinyl pyridineDiarylamideMelanomaArticlehttps://doi.org/10.1016/j.bmcl.2016.01.014