Ibrahim M.S.Rogers S.Mahmoudy N.Murray M.Szczygiel A.Green B.Alexander B.D.Griffiths P.C.Faculty of Engineering and ScienceUniversity of GreenwichMedway CampusChatham MaritimeKent ME4 4TBUnited Kingdom; Pharmaceutics DepartmentFaculty of PharmacyModern Science and Arts University26 July Mehwar Road Intersection with Wahat RoadCairoEgypt; Science and Technology Facilities CouncilISIS FacilityRutherford Appleton LaboratoryDidcotOxfordshire OX11 OQXUnited Kingdom; AkzoNobelWexham RoadSloughBerkshire SL2 5DSUnited Kingdom2020-01-092020-01-092019219797https://doi.org/10.1016/j.jcis.2018.12.059PubMed ID : 30579216https://www.sciencedirect.com/science/article/abs/pii/S0021979718315005ScopusHypothesis: The presence of surfactant modulates the surface-chemistry-specific interaction of hard colloidal particles (latex) with HEUR polymers, principally through introducing a preferential solution interaction rather than a competitive surface interaction; addition of surfactant leads to a preponderance of polymer/surfactant solution complexes rather than surface-bound complexes. Experiments: A range of model formulations comprising a hexyl end-capped urethane polymer (C6-L-(EO100-L)9-C6), sodium dodecylsulfate (SDS) and a series of polystyrene-butylacrylate latices (PS-BA-L) have been characterised in terms of rheology, particle surface area (solvent relaxation NMR), polymer conformation (small-angle neutron scattering) and solution composition to build up a detailed picture of the distribution of the HEUR in the presence of both surfactant and latex. Findings: There is very weak adsorption of C6-L-(EO100-L)9-C6 to only the most hydrophobic latex surface studied, an adsorption that is further weakened by the addition of low levels of surfactant. Macroscopic changes in the hydrophobic latex system may be interpreted in terms of bridging flocculation at low polymer concentrations. No adsorption of C6-L-(EO100-L)9-C6 is observed in the case of hydrophilic surfaces. In most cases, the observed behaviour of the ternary system (polymer/surfactant/particle) is highly reminiscent of the binary (polymer/surfactant) system at the appropriate composition, suggesting that the polymer/surfactant solution interaction is the dominant one. 2018EnglishHEURLatexPGSE-NMRRheologySANSSDSSolvent relaxation NMRAdsorptionElasticityEstersHydrophobicityLatexesNeutron scatteringRheologySodium dodecyl sulfateSolsSurface chemistryBridging flocculationHEURHydrophobically modified ethoxylated urethanesImpenetrable surfacesPgse nmrPolymer concentrationsSANSSolvent relaxationPolymersacrylic acid butyl esterdodecyl sulfate sodiumhydrophobically modified ethoxylated urethanelatexpolystyrenepolyurethansurfactantunclassified drugadsorptionArticlechemical compositionchemical interactionchemical modificationconcentration (parameters)conformationflocculationhydrophobicitymodelneutron scatteringpriority journalsurface propertyArticlehttps://doi.org/10.1016/j.jcis.2018.12.059PubMed ID : 30579216