Sakr T.M.Ibrahim A.B.Fasih T.W.Rashed H.M.Radioactive Isotopes and Generators DepartmentHot Laboratories CentreAtomic Energy AuthorityCairo13759Egypt; Pharmaceutical Chemistry DepartmentFaculty of PharmacyOctober University of Modern Sciences and Arts (MSA)GizaEgypt; Labeled Compounds DepartmentHot Labs CenterAtomic Energy AuthorityP.O. Box 13759CairoEgypt2020-01-092020-01-0920172365731https://doi.org/10.1007/s10967-017-5560-zPubMed ID :https://t.ly/R0KzvScopusMSA Google ScholarThe current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al. 99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4. 0.11% ID/g) and faster (15. min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. 2017, Akadmiai Kiad, Budapest, Hungary.EnglishOctober University for Modern Sciences and ArtsUniversity for Modern Sciences and ArtsMSA Universityجامعة أكتوبر للعلوم الحديثة والآداب99Mo/99mTc generatorHeart imagingLidocaineMyocardial perfusionaluminumlidocainemolybdenum 99molybdic acidprocainamidetechnetium 99mvalsartananimal experimentanimal tissueArticlecardioselectivitycontrolled studyelutiongelisotope labelingmousemyocardial perfusion imagingnonhumanradioactivityreceptor affinitystructure analysisPreparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gelArticlehttps://doi.org/10.1007/s10967-017-5560-zPubMed ID :