Said M.M.Taher A.T.El-Nassan H.B.El-Khouly E.A.Pharmaceutical Organic Chemistry DepartmentFaculty of PharmacyCairo University33 Kasr El-Aini StreetCairo11562Egypt; Organic chemistry DepartmentFaculty of PharmacyOctober University for Modern Sciences and Arts (MSA)GizaEgypt2020-01-092020-01-0920169226168https://doi.org/10.1007/s11164-016-2487-xPubMed ID :https://t.ly/2dre5ScopusAbstract: Two series of 4-phenyl-5-cyanopyrimidin-6-one derivatives bearing various S-alkyl or S-acyl moieties at position 2 were prepared as cytotoxic agents. All compounds were tested for possible anti-cancer activity on two cell lines (MCF-7 and HCT-116). The MCF-7 cell line was found to be more sensitive than the HCT-116 cell line to the action of the compounds. Compound 8g was the most potent on the MCF-7 cell line with IC50 18.3�nM/mL, whereas its IC50 on the normal cell line (MRC-5) was 64.38�nM/mL, indicating its safety and selectivity towards the MCF-7 cell line. On the other hand, compound 8d was the most potent compound on the HCT-116 cell line with IC50 23.8�nM/mL. Compound 8g was screened against five kinases. The compound showed selective inhibitory activity against pim1 kinase with IC50 11.62��M. Graphical Abstract: [Figure not available: see fulltext.] � 2016, Springer Science+Business Media Dordrecht.EnglishAntitumor activityHCT-116MCF-7pim1PyrimidineCell cultureCytologyEnzymesAnti-tumor activitiesHCT-116MCF-7pim1PyrimidineCellsArticlehttps://doi.org/10.1007/s11164-016-2487-xPubMed ID :