El-Feky G.S.Abdulmaguid R.F.Zayed G.M.Kamel R.Department of Pharmaceutical TechnologyNational Research CenterCairoEgypt; Department of PharmaceuticsFaculty of PharmacyOctober University for Modern Sciences and ArtsCairoEgypt; Department of Oral Medicine and PeriodontologyDepartment Faculty of DentistryOctober University for Modern Sciences and ArtsCairoEgypt; Department of Pharmaceutics and Industrial PharmacyFaculty of PharmacyAl-Azhar University at AssiutAssiutEgypt2020-01-092020-01-09201810717544https://doi.org/10.1080/10717544.2017.1413445PubMed ID 29226726https://t.ly/lW82RScopusThe current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinyl-pyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy. Nine ketorolac/lidocaine lyophilized wafers were formulated and assessed for their hydration capacity, mucoadhesion ability and in vitro release profile to select the optimum system for further clinical investigation. Wafer F6 containing 2:1 sodium alginate to PVP K-25 and 10% glycerol showed optimum properties and was selected for the clinical study. Twenty patients were included in the study and the ketorolac/lidocaine wafer was assessed versus a market product. Visual pain analog was evaluated daily for the first week and wound healing index was evaluated for one week, two weeks and one month following the procedure. The developed ketorolac/lidocaine polymeric wafer proved to be an effective method of reducing pain and discomfort together with enhancing wound healing following gingivectomy. � 2017 The Author(s).EnglishGingivectomyKetorolac/lidocaine waferPolyvinylpyrrolidone K-25Sodium alginateVisual analogue scale (VAS)Wound healing index (WHI)alginic acidglycerolketorolac trometamollidocainepovidonealginic acidglucuronic acidhexuronic acidketorolaclidocainelocal anesthetic agentnonsteroid antiinflammatory agentpolymerpovidoneadolescentadultageArticlebone metabolismclinical articlecrown lengtheningdental proceduredrug distributiondrug formulationeffective concentrationex vivo studyfreeze dryinggingivectomyhumanhydrationin vitro studyinflammationmucoadhesionpostoperative painpriority journalscanning electron microscopyvisual analog scalewater absorptionwound fluidwound healingchemistrydrug delivery systemdrug effectfemalemalemetabolismmouth mucosapainpain measurementprocedureswound healingyoung adultAdolescentAdultAlginatesAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalDrug Delivery SystemsFemaleGingivectomyGlucuronic AcidHexuronic AcidsHumansKetorolacLidocaineMaleMouth MucosaPainPain MeasurementPolymersPovidoneWound HealingYoung AdultArticlehttps://doi.org/10.1080/10717544.2017.1413445PubMed ID 29226726