Nour Sh. El-GendyM. Shaaban SadekHussein N. NassarAhmad Mustafa2025-04-042025-04-042025-02-26El-Gendy, N. S., Sadek, M. S., Nassar, H. N., & Mustafa, A. (2025). Eco‐Friendly Extraction of Sustainable and Valorized Value‐Added Products From Ulva fasciata Macroalgae: A Holistic Technoeconomic Analysis. International Journal of Biomaterials, 2025(1). https://doi.org/10.1155/ijbm/5811057https://doi.org/10.1155/ijbm/5811057https://repository.msa.edu.eg/handle/123456789/6371Q3Te present work conducts a detailed technoeconomic analysis of an environmentally friendly zero-waste biorefnery process to valorize marine Ulva fasciata macroalgae into diferent sustainable value-added products. Te proposed sequential fully integrated process yielded 34.89% mineral-rich water extract (MRWE), 2.61 ± 0.5% chlorophyll, 0.41 ± 0.05% carotenoids, 12.55 ± 1.6% starch, 3.27 ± 0.7% lipids, 22.24 ± 1.8% ulvan, 13.37 ± 1.5% proteins, and 10.66 ± 0.9% cellulose. Te Aspen Plus software, utilizing the nonrandom two-liquid (NRTL) model, was applied for process design, simulation, and technoeconomic analysis. Key fndings include a positive net present value (NPV) of $49,755,544.90, a high return on investment (ROI) of 485%, and an internal rate of return (IRR) of 17%. Te anticipated payback period is 7 years, indicating a quick recovery of the initial investment. Tese fndings confrm that Ulva fasciata is a promising resource in the biorefnery industry, providing a viable and eco-friendly alternative for the production of bio-based products and a new market for seaweed-based products.en-USbiorefnery processinternal rate of returnpayback periodreturn on investmentsimulationUlva fasciataArticlehttps://doi.org/10.1155/ijbm/5811057