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Cited 101 times. 25 Oetterli, M., Kiener, P., Mericske-Stern, R. A Longitudinal Study on Mandibular Implants Supporting an Overdenture: The Influence of Retention Mechanism and Anatomic-Prosthetic Variables on Periimplant Parameters (2001) International Journal of Prosthodontics, 14 (6), pp. 536-542. Cited 54 times. 26 Karabuda, C., Tosun, T., Ermis, E., Ozdemir, T. Comparison of 2 retentive systems for implant-supported overdentures: Soft tissue management and evaluation of patient satisfaction (2002) Journal of Periodontology, 73 (9), pp. 1067-1070. Cited 30 times. doi: 10.1902/jop.2002.73.9.1067 View at Publisher 27 Walton, J.N. A randomized clinical trial comparing two mandibular implant overdenture designs: 3-Year prosthetic outcomes using a six-field protocol (2003) International Journal of Prosthodontics, 16 (3), pp. 255-260. Cited 52 times. 28 Chung, K.-H., Chung, C.-Y., Cagna, D.R., Cronin Jr., R.J. 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Cited 6 times. http://www.elsevier-international.com/journals/ijom/ doi: 10.1016/j.ijom.2017.10.018 View at Publisher 41 Ali, R.M.M., Alqutaibi, A.Y., El-din Gomaa, A.S., Abdallah, M.F. Effect of submerged vs nonsubmerged implant placement protocols on implant failure and marginal bone loss: A systematic review and meta-analysis (2018) International Journal of Prosthodontics, 31 (1), pp. 15-22. Cited 4 times. http://www.quintpub.com/journals/ijp/fulltext.php?article_id=17987 doi: 10.11607/ijp.5315 View at Publisher336572https://doi.org/10.3290/j.qi.a44144https://t.ly/oZtPhttps://t.ly/ACbcScopusObjectives: To evaluate the influence of implant splinting on peri-implant marginal bone level and implant failures in com pletely edentulous patients who have been rehabilitated with mandibular implant overdentures. Method and materials: A literature search of electronic databases (PubMed and Cochrane Central Register of Controlled Trials [CENTRAL]) was performed, with the last search conducted in July 2019. Randomized con trolled trials with at least a 12-month follow-up period were selected. The review and meta-analysis were performed in ac cordance with PRISMA guidelines. Two comparisons were in cluded in the meta-analysis: (1) Two-implant supported ball versus two-implant supported bar mandibular overdenture; (2): Two- versus four-implant supported bar mandibular overden ture. Results: Six randomized controlled trials fulfilled the inclu sion criteria and were included in a quality assessment and me ta-analysis. Pooled data revealed a nonsignificant difference in marginal bone level (I2 = 0%; P = 1; mean difference = 0.00; 95% CI −0.37 to 0.37) and implant failures (P = .24; risk ratio = 6.07; 95% CI 0.30 to 121.33) when two-implant ball overdentures were compared to two-implant bar overdentures. Similarly, there was no significant difference in marginal bone level (I2 = 59%; P = .59; mean difference = −0.16; 95% CI −0.73 to 0.41) or implant failures (I2 = 0%; P = .36; risk ratio = 2.03; 95% CI 0.45 to 9.16) when two- versus four-implant bar overdentures were compared. Conclusion: Based on the findings of the meta-ana lysis, there is no influence of implant splinting on peri-implant marginal bone level and implant failures for completely edentu lous patients rehabilitated with mandibular implant overden tures. However, this result should be interpreted with caution due to the limited number of analyzed studies, most of them considered at unclear risk of bias. Well-designed randomized controlled trials with follow-up periods of at least 5 years are highly recommended to establish evidence with regard to the influence of implant splinting on mandibular overdentures. © 2020 Quintessence Publishing Co., Ltd.en-USDental implantsImplant failureMandibular overdentureMarginal bone lossSplintingedentulousnesshumanimplant-supported dentureDental ImplantsDental Prosthesis, Implant-SupportedArticlehttps://doi.org/10.3290/j.qi.a44144