Mohareb R.M.El-Sharkawy K.A.Hussein M.M.El-Sehrawi H.M.Faculty of PharmacyOrganic Chemistry DepartmentOctober University for Modern Sciences and Arts (MSA)El-Wahat Road6 October CityEgypt; Department of ChemistryFaculty of ScienceCairo UniversityGizaA. REgypt; Faculty of Pharmacy (Girls)Pharmaceutical Chemistry DepartmentAl-Azhar UniversityNasr CityCairoA. REgypt2020-01-252020-01-2520109751459https://doi.org/https://t.ly/w1mAxScopusThe reaction of cyanoacetylhydrazine (1) with ?-bromo(4-methoxyacetophenone) (2) gave the hydrazide-hydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.English1,3,4-triazineAntidepressantHydrazide-hydrazonePyridineSedative3 cyano 4,6 dimethyl 2 oxo 1 imino (4 methoxy omega hydrazinoacetophenonylidieno)pyridine3 cyano 6 hydroxy 4 methyl 2 oxo 1 imino(4 methoxy omega hydrazinoacetophenoylidieno)pyridine4 amino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene)acetonitrilo] 1,2,4 triazine4 methoxy omega bromoacetophenone cyanoacetylhydrazone4 methoxy omega cyanoacetophenone cyanoacetylhydrazone4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazone4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazone4 methoxy omega thiocyanoacetophenone cyanoacetylhydrazone4 phenylamino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopene)acetonitrilo] 1,2,4 triazinealpha benzal 4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazonealpha benzal 4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazoneethyl 4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene 3 carboxylate)acetonitrilo] 1,2,4 triazineethyl 4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopen 3 carboxylate)acetonitrilo] 1,2,4 triazinehydrazine derivativehydrazone derivativeimipramineindometacinunclassified druganalgesic activityanimal experimentantidepressant activityarticlecontrolled studycyclizationdrug determinationdrug mechanismdrug megadosedrug potencydrug screeningdrug structuredrug synthesisexperimental mousefemaleforced swimming testlow drug dosemalemotor activitymousenonhumansedationArticlehttps://doi.org/