Sensitive Allele-Specific PCR Assay Able to Detect FGFR3 Mutations in Tumors and Urine from Patients with Urothelial Cell Carcinoma of the Bladder

A Bakkar, AshrafQuach, VivianeLe Borgne, AnaïgToublanc, MarianneHenin, DominiqueWallerand, HervéRadvanyi, FrançoisBittard, HuguesRavery, VincentBoccon Gibod, LaurentGil Diez de Medina, SixtinaK Chopin, DominiqueGrandchamp, Bernard2020-02-122020-02-1220050009-9147https://doi.org/10.1373/clinchem.2005.049619https://cutt.ly/frJTQwuMSA Google ScholarActivating somatic point mutations in exons 7, 10, and 15 of the FGFR3 gene are frequently observed in urothelial cell carcinoma (UCC) (1)(2). These mutations have been found primarily in superficial papillary pTa tumors and were absent in carcinoma in situ (3).enUniversity for plasmaFGFR3PCRCell CarcinomaSensitive Allele-Specific PCR Assay Able to Detect FGFR3 Mutations in Tumors and Urine from Patients with Urothelial Cell Carcinoma of the BladderArticlehttps://doi.org/10.1373/clinchem.2005.049619