Mohareb R.Moustafa H.October University for Modern Sciences and ArtsEl Wahaat RoadOctober CityEgypt; Chemistry DepartmentFaculty of ScienceCairo UniversityGizaEgypt; Applied Medical SciencesDepartment Community College in QuaryatAl Jouf UniversityAl JoufSaudi Arabia2020-01-252020-01-25201113300075https://doi.org/10.2478/v10007-011-0001-yPubMed ID 21406343https://t.ly/r8G1WScopusThe aim of the work was to synthesize heterocyclic compounds from 2-aminoprop-1-ene-1,1,3-tricarbonitrile and to study their antitumor activities. The title reagent reacted with cyclohexanone to give the ethylidene derivative 2. The reactivity of the latter product towards different chemical reagents was studied to give tetrahydronaphthalene, hexahydroisoquinoline and hexahydrocinnoline derivatives. The newly synthesized products were screened as antitumor agents on the in vitro growth of three human tumor cell lines representing different tumor types, namely, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268). It was found that some of these compounds showed inhibitory effects on the three cell lines, indicating their potential use in the development of oncology products.Englishantitumor activityhexahydrocinnolinehexahydroisoquinolinetetrahydronaphthalene2 (amino(3 oxo 2 (1,4 ditolylamino) 2,3,5,6,7,8 hexahydrocinnolin 4 yl)methylene)malononitrile2 [amino(2,3 diamino 1 phenyl 1,2,5,6,7,8 hexahydroisoquinolin 4 yl)methylene]malononitrile2 [amino[2,3,5,6,7,8 hexahydro 3 imino 2 (1,4 ditolylcinnoline) 4 yl]methylene]malononitrile2 amino 3 (2 benzylidene 6 bromocyclohexylidene)prop 1 ene 1,1,3 tricarbonitrile2 amino 3 (2 benzylidenecyclohexylidene)prop 1 ene 1,1,3 tricarbonitrile3 amino 2 cyano 4 [2 (1,4 ditolyl hydrazono) cyclohexylidene]prop 1 ene 1,1,3 tricarbonitrile3 amino 3 (3,5 diamino 4h pyrazol 4 ylidene) 2 cyclohexylidene propanonitrile3 amino 3 [3 amino 5 imino 1 phenyl 1h pyrazol 4 (5h) ylidene] 2 cyclohexylidenepropanonitrile3 amino 4 (1 amino 2,2 dicyanovinyl) 1 phenyl 5,6,7,8 tetrahydro 1 phenylnaphthalene 2 carbonitrile4 [2 benzylidenecyclohexylidene)(cyano)methyl] 1,2,3,6 tetrahydro 6 imino 1 phenyl 2 thioxopyrimidine 5 carbonitrileantineoplastic agentcyanidecyclohexanoneethyl 3 amino 4 (1 amino 2,2 dicyanovinyl) 5,6,7,8 tetrahydro 1 phenylnaphthalene 2 carboxylateisoquinoline derivativetetralin derivativeunclassified drugantineoplastic activityarticlebrain cancerbreast adenocarcinomacancer cell culturecontrolled studydrug effectdrug synthesishumanhuman cellin vitro studylung non small cell cancerAntineoplastic AgentsCell Line, TumorDrug Screening Assays, AntitumorHeterocyclic Compounds, 2-RingHumansIsoquinolinesNeoplasmsTetrahydronaphthalenesArticlehttps://doi.org/10.2478/v10007-011-0001-yPubMed ID 21406343