Yasmin M. AttiaSamer A. TadrosSally A. FahimDoaa M. Badr2025-04-022025-04-022025-03-24Attia, Y. M., Tadros, S. A., Fahim, S. A., & Badr, D. M. (2025). Role of noncoding RNA as a pacemaker in cancer stem cell regulation: a review article. Journal of the Egyptian National Cancer Institute, 37(1). https://doi.org/10.1186/s43046-025-00266-2https://doi.org/10.1186/s43046-025-00266-2https://repository.msa.edu.eg/handle/123456789/6365Q3Accumulated evidence supported the crucial role of a tiny population of cells within the tumor called cancer stem cells (CSCs) in cancer origination, and proliferation. Additionally, these cells are distinguished by their self-renewal, diferentiation, and therapeutic resistance capabilities. Interestingly, many studies recorded dysregulation of diferent types of noncoding RNAs, such as microRNA (miRNA) and long non-coding RNA (LncRNA), in cancer cells as well as CSCs. Moreover, several studies also supported the regulation of the transcription factors and signaling pathways required for CSC progression by these noncoding RNAs. However, the exact biological functions of all these noncoding RNAs are not well understood yet. These fndings are of great interest, implying usage of noncoding RNA as therapeutic tool to target these cells. In this review, we provide an insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfullyen-USCancerCancer stem cellsNon-coding RNAMicroRNALong non-coding RNAArticlehttps://doi.org/10.1186/s43046-025-00266-2