Abdallah M.A.Gomha S.M.Abbas I.M.Kazem M.S.H.Alterary S.S.Mabkhot Y.N.Department of ChemistryFaculty of ScienceCairo UniversityGiza12613Egypt; Department of ChemistryFaculty of DentistryOctober University for Modern Science & ArtsGiza12613Egypt; Department of ChemistryCollege of ScienceKing Saud UniversityP.O. Box 2455Riyadh11451Saudi Arabia2020-01-092020-01-09201720763417https://doi.org/10.3390/app7080785PubMed ID :https://t.ly/veeBYScopusA new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl-1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines. � 2017 by the authors.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversityAntitumor activityMulticomponent reactionsPyrazolesPyrazolyl-pyridinesPyridinesArticlehttps://doi.org/10.3390/app7080785PubMed ID :