Mostafa, AmrEl Baz, MahaTaher, HebaShabka, Amr2022-12-102022-12-102022-1210.47750/pnr.2022.13.S09.407http://repository.msa.edu.eg/xmlui/handle/123456789/5280Aim: to investigate the retention and potential to prevent lesion progression of a bioactive resin material compared to a conventional resin-based flowable composite during management of initial carious lesion in adult population over an 18 months period. Methodology: Twenty-four subjects with an upper or lower molar that has an ICDAS score 1 or 2 on its occlusal surface, were selected for this study. The subjects were divided randomly and equally into two groups. Group I was assigned to be sealed with a nano-filled giomer based sealant (Beautifil Injectable X, Shofu Dental Corp.) while Group II was assigned to be sealed with a nano-filled conventional flowable composite (Filtek z350 XT, 3m ESPE). Both sealants were applied after acid conditioning and the application of a bonding agent. The sealants were then evaluated for retention and caries progression after six, twelve and eighteen months. Results: Most sealants remained in-situ after eighteen months. There was a non-significant difference between the two groups in terms of retention or caries progression. Only one sealant from each group progressed to ICDAS score 3. Conclusions: Both fissure sealants can successfully seal initially carious fissures. The nano-filled giomer flowable composite could be promising as a bioactive fissure sealant.en-USFissure sealantmedical modelS-PRG fillersresin sealantArticlehttps://doi.org/10.47750/pnr.2022.13.S09.407