Mohareb, Rafat M.Abbas, Nermeen S.Abdelaziz, Mahmoud A.2019-12-042019-12-042014Cited References in Web of Science Core Collection: 320039-128Xhttps://doi.org/10.1016/j.steroids.2014.04.011https://www.sciencedirect.com/science/article/pii/S0039128X14000828Accession Number: WOS:000338613000008The reaction of androstenedione with either malononitrile or ethyl cyanoacetate and aromatic aldehydes 2a-c gave the pyran derivatives 4a-f, respectively. On the other hand, the reaction of androstenedione with thiourea and the aromatic aldehydes 2a-c gave the pyrimidine derivatives 6a-c, respectively. Compound 6b reacted with 2-bromo-1-arylethanone derivatives 7a-d to give the indeno[2,1-e]thiazole derivatives 8a-d. Some of the produced compounds were used for further heterocyclization reactions. The cytotoxicity of the newly obtained products was evaluated against some cancer cell lines and a normal cell line. (C) 2014 Elsevier Inc. All rights reserved.enAndrostenedionePyranPyrimidineThienoThieno[2,3-b]pyridineCytotoxicityHUMAN STEROID SULFATASE17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-3ESTRONE DERIVATIVESPOTENT INHIBITORSArticlehttps://doi.org/10.1016/j.steroids.2014.04.011