Naga A.A.E.Yousef M.Ramadan R.Bahgat S.F.Alshawwa L.Operative Dentistry DepartmentFaculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia; Operative Dentistry DepartmentModern Science and Arts UniversityCairoEgypt; Operative Dentistry DepartmentDentistry ProgramBatterjee Medical CollegeJeddahSaudi Arabia; Fixed Prosthodontics DepartmentModern S Cience and Arts UniversityCairoEgypt; Fixed Prosthodontics DepartmentDentistry ProgramBatterjee Medical CollegeJeddahSaudi Arabia; Medical E Ducation DepartmentFaculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia; Department of Operative DentistryFaculty of DentistryKing Abdulaziz UniversityPO Box 80209Jeddah21589Saudi Arabia2020-01-092020-01-09201511791357https://doi.org/10.2147/CCIDE.S80462PubMed ID :https://t.ly/xRRGwScopusObjective: The aim of the study reported here was to evaluate the performance of a self-adhesive flowable composite and two self-etching adhesive systems, when subjected to cyclic loading, in preventing the nanoleakage of Class V restorations. Methods: Wedge-shape Class V cavities were prepared (4�2�2 mm [length � width � depth]) on the buccal surfaces of 90 sound human premolars. Cavities were divided randomly into three groups (n=30) according to the used adhesive (Xeno� V [self-etching adhesive system]) and BOND-1� SF (solvent-free self-etching adhesive system) in conjunction with Artiste � Nano Composite resin, and Fusio� Liquid Dentin (self-adhesive flowable composite), consecutively. Each group was further divided into three subgroups (n=10): (A) control, (B) subjected to occlusal cyclic loading (90N for 5,000 cycles), and (C) subjected to occlusal cyclic loading (90N for 10,000 cycles). Teeth then were coated with nail polish up to 1 mm from the interface, immersed in 50% silver nitrate solution for 24 hours and tested for nanoleakage using the environmental scanning electron microscopy and energy dispersive analysis X-ray analysis. Data were statisti? cally analyzed using two-way analysis of variance and Tukey's post hoc tests (P?0.05). Results: The Fusio Liquid Dentin group showed statistically significant lower percentages of silver penetration (0.55 ?) compared with the BOND-1 SF (3.45 ?) and Xeno V (3.82 ?) groups, which were not statistically different from each other, as they both showed higher silver penetration. Conclusion: Under the test conditions, the self-adhesive flowable composite provided bet? ter sealing ability. Aging of the two tested adhesive systems, as a function of cyclic loading, increased nanoleakage. � 2015 Abo El Naga et al.EnglishClass VCyclic loadingFlowable compositeNanoleakageSelf-adhesiveArticlehttps://doi.org/10.2147/CCIDE.S80462PubMed ID :