Mohamed Tamam, AhmedMamdouh Mostafa, HebaMustafa Ahmed, MayTarek Omar, Sherouk2020-12-202020-12-202020Copyright © 2020 MSA University. All Rights Reserved.http://repository.msa.edu.eg/xmlui/handle/123456789/4260A project submitted in partial fulfillment to B.SC degree in pharmaceutical science for October University of Modern Science and ArtsEpilepsy is considered as a disturbance in the balance of the electrical system of the brain, which leads to seizures that can affect both adults and children (Manford, 2017). Unfortunately it is difficult to be treated due to the fact that the most of centrally active drugs in brain suffer of decreased in efficiency to pass the blood brain barrier due to their hydrophilicity, such as antiepileptic drugs as Zonisamide which works by blocking the calcium, potassium and sodium channels, in addition to reducing the glutamate excitation and increasing GABA to reduce the epileptic seizures. The nanodiamond was selected as a carrier, due to its small particle size and biocompatibilities. Which make it more favorable than other nanocarriers for this purpose. Thus, our study aims to prepare a suitable formula Zonisamide loaded Nanodiamonds for brain targeting through nose to brain delivery. Zonisamide loaded nanodiamond delivery system was prepared and then being characterized for various in vitro aspects [particle size, % of drug loading, zeta potential, drug loading , FTIR and surface morphological structures through the Transmission Electron Microscopy, Particle size for the formula of choice was 193.73 nm ,zeta potential was found to be 18.93 mV , with high drug loading of Zonisamide on Nanodiamonds of 83.821 ,TEM confirmed the particle size and it's morphological structure and finally FTIR which confirmed the loading of Zonisamide, Thus it can be concluded that the Zonisamide was successfully loaded on nanodiamonds with suitable particle size for brain delivery.enMSA UniversityDSpace EgyptUniversity of Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابPharmaceuticsNANOTECHNOLOGYDRUG BRAINEpilepsyNanodiamondZonisamideIntranasal routeOther