Othman, Mohamed SKhaled, Azza MAl‑Bagawi, Amal HFareid, Mohamed AHameed, Reda AAbu Zahra, Fatama AAbdel Moneim, Ahmed E2022-01-302022-01-3026/01/2022https://doi.org/10.1007/s11356-022-18824-9https://bit.ly/3g6BZEWDownload PDF Download PDF Research Article Published: 26 January 2022 Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction Mohamed S. Othman, Azza M. Khaled, …Ahmed E. Abdel Moneim Show authors Environmental Science and Pollution Research (2022)Cite this article 4 Accesses Metricsdetails Abstract The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to investigate the anti-diabetic properties of both ES total extract (ESTE) and its high flavonoids fraction (ESHFF) in experimental diabetes induced by streptozotocin (STZ) injection in rats. Forty-two rats were divided into six groups. Diabetes was induced using STZ (55 mg/kg). Seven days after STZ administration, the diabetic animals were treated daily with ESTE, ESHFF, or metformin (MET) as a standard anti-diabetic drug for 28 days. Blood and tissues samples were collected for biochemical, molecular, and histological investigations. Both ESTE and ESHFF demonstrated anti-diabetic properties, as evidenced by lowering glucose levels and increasing the levels of insulin, insulin receptor expression rate, and glycogen synthesis. Additionally, ESTE as well as ESHFF alleviated diabetic complications in the kidneys and liver by decreasing oxidative stress, modulating inflammatory mediators, and suppressing the apoptotic cascade along with correcting diabetic dyslipidemia. It could be deduced that Hail ES extracts could play a role in the treatment of type 2 diabetes and diabetes-related lesions as well as oxidative damage in hepatic and renal tissues.en-USEchinops spinosus Diabetes mellitus High favonoids fraction Antioxidant Lipid metabolismArticlehttps://doi.org/10.1007/s11356-022-18824-9