Alkyl heterocycles in heterocyclic synthesis (II): Novel synthesis of isoquinoline, thiazolopyridine, and thieno[2,3-b]pyridine derivatives

Abu Elmaati, TM2020-01-142020-01-142004Cited References in Web of Science Core Collection: 140022-152Xhttps://doi.org/10.1002/jhet.5570410614https://cutt.ly/TrxWkWeAccession Number: WOS:000226357900014Treating 5 - (4-phenylcarboxamido)-3-cyano-4-methylpyridin-2(1H)thione (3) with elemental sulfur yielded thienopyridine 4. Compound 4 reacts with acrylonitrile to give isoquinoline 7. Compound 7 was also, prepared from 3 and methylenemalononitrile. Reaction of 3 with dimethylacetylene dicarboxylate (DMAD) gave the pyridothiazole 9. Also, 3 reacted with N,N-dimethylchloroacetamide (10) to afford compound 11 which further reacted with the reagents 12, 13 and 14 providing the thieno [2,3-b]pyridine derivatives 15, 16 and 17 respectively.enAlkyl heterocycles in heterocyclic synthesis (II): Novel synthesis of isoquinoline, thiazolopyridine, and thieno[2,3-b]pyridine derivativesArticlehttps://doi.org/10.1002/jhet.5570410614