Sweed N.Sabry N.Azab T.Nour S.Faculty of PharmacyMSA University6th October CityEgypt; Clinical PharmacyFaculty of PharmacyCairo UniversityCairoEgypt; Faculty of MedicineCairo UniversityCairoEgypt2020-01-252020-01-252011264806https://doi.org/https://t.ly/XA1qbScopusAim. The aim of this study was to compare combined spinal epidural (CSE), epidural (E) and IV pethidine analgesia and their effects on the mother, fetus, newborn and the labor course. Methods. This is a prospective parallel single blind study, where 60 women in active labor were recruited and were allocated to five subgroups to receive analgesia by different routes. The mother and the fetus were assessed. The results were recorded and compared using Visual Analogue Scale (VAS) and modified Bromage scale for motor block, in addition to other clinical findings. Results. The duration of first stage of labor was significantly longer in the E group, compared with the CSE and IV pethidine groups. When the pain control achieved by CSE bupivacaine and lidocaine was compared with the corresponding epidural, it was found that the first technique achieved better pain control. Women who received pethidine had higher incidence of nausea and vomiting compared to those received CSE or E analgesia. There was no significant difference between the five groups with respect to other side effects. Conclusion. Regional analgesia especially CSE using bupivacaine or lidocaine is a safe effective method for analgesia in labor with relative better efficacy of bupivacaine.EnglishAnalgesia, epiduralDelivery, obstetricLabor, obstetricbupivacainefentanyllidocainepethidineadultApgar scorearterial pressurearticleclinical assessmentcontrolled studydrowsinessdrug safetyepidural anesthesiafemalefetus heart ratefetus outcomefeverheart ratehumanhypotensionintermethod comparisonintravenous anesthesialaborloading drug dosemajor clinical studynauseanewborn assessmentoutcome assessmentparallel designprospective studypruritusrandomized controlled trialrating scaleregional anesthesiasedationside effectsingle blind procedurestatistical significancevisual analog scalevomitingAdolescentAdultAnalgesia, EpiduralAnalgesia, ObstetricalAnalgesics, OpioidAnesthetics, LocalBupivacaineFemaleFentanylHumansInfusions, IntravenousLabor Stage, FirstLabor, ObstetricLidocaineMeperidinePregnancyProspective StudiesSingle-Blind MethodYoung AdultArticlehttps://doi.org/