A Elkady, Omar2019-10-282019-10-282015[1] R. K. Verma, and Sanjay Garg, “Current Status of Drug Delivery Technologies and Future Directions,” Pharmaceutical Technology On-Line, 25 (2), 1–14 (2001). [2] N. Dixit, S. D. Maurya, B. P. Sagar, “Sustained release drug delivery system,” Volume 1(3), Page 305, May-June 2013. [3] K. Khande, H. Saluja, and U. Mahindra, “Primary and secondary closure of the surgical wound after removal [4] D. E. Becker, “Basic and Clinical Pharmacology of Glucocorticosteroids,” vol. 60:25–32, Nov. 2012. [5] Y. Kosen, H. Miyaji, A. Kato, T. Sugaya, and M. Kawanami, “Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs,” 47(5):626-34, Mar. 2012. [6] H. Ueno, T. Mori, and T. Fujinaga, “Topical formulations and wound healing applications of chitosan,” Advanced Drug Delivery Reviews, vol. 52, no. 2, pp. 105–115, 2001. Pharmaceutics, vol. 251, no. 1-2, pp. 175–181, 2003. [7] J. Irwandi, S. Faridayanti, E. S. M. Mohamed, M. S. Hamzah, H. H. Torla, and Y. B. Che Man, “Extraction and characterization of gelatin from different marine fish species in Malaysia,” International Food Research Journal, 16: 381-389, (2009). [8] V. Kumar, A. Sharma, G. Joshi, V. Dhillon, “Recent Advances InNdds (Novel Drug Delivery System) For Delivery Of Anti- Hypertensive Drugs,” Int. J. Drug Dev. & Res., 3 (1):252-259, March 2011. [9] The United States Pharmacopeia 24& National Formulary19, Asian edition, United States Pharmacopeial convention, 2000, 763.https://doi.org/https://t.ly/W3zKvMSA Google ScholarThe extraction of impacted third molar teeth can significantly lead to postoperative pain, swelling and trismus which delay hospital discharge. Dexamethasone steroid and Diclofenac are commonly prescribed to prevent inflammatory sequelae and relieve the associated pain. In this study, gelatin/chitosan blend was used for the preparation of dexamethasone-diclofenac sponge to be implanted directly to the socket benefiting from (1) the biodegradable nature of the polymers used as taking out the sponge after treatment always causes new damage to the wound.(2) The interaction between positively charged chitosan and negatively charged gelatin. The conditions expected to affect the stability of gelatin foams were optimized and the sponge was prepared by the lyophilization of stable foams generated by stirring a mixture of 7% aqueous gelatin and 2.5% chitosan in 1% acetic acid in a ratio of 1: 5 respectively at 1000 rpm for 10 minutes. Scanning Electron Microscopy (SEM) was used to elucidate the internal structure of the developed sponge where drug crystals were detected on the lamellae and within pores of the sponge. In general, sponge formulae D, E and F showed higher and fast absorption behaviour reaching up to 2023% of its weight after 15 minutes onlyenChitosanGelatinArticlehttps://doi.org/