Mohareb R.M.Louca N.A.Elmegeed G.A.Hana H.Y.Departament of Organic ChemistryFaculty of PharmacyOctober University for Modem Sciences and Arts (MSA)El-Wahaat RoadOctober CityEgypt; Chemistry DepartmentFaculty of ScienceCairo UniversityGizaEgypt; Hormone DepartmentNational Research CentreDokkiGizaEgypt2020-01-252020-01-2520097179324https://doi.org/10.4067/S0717-97072009000200018PubMed ID :https://t.ly/XAzAVScopusTryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetonitrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding ?-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.English13 - oxazinePyrazdPyridineTeyptophaneArticlehttps://doi.org/10.4067/S0717-97072009000200018PubMed ID :