Abd Elkodous, MohamedEl-Husseiny, Hussein MEl-Sayyad, Gharieb SHashem, Amr HosnyDoghish, Ahmed SElfadil, DouniaRadwan, YasmineEl-Zeiny, Hayam MBedair, HebaIkhdair, Osama AHashim, HishamSalama, Ahmed MAlshater, HebaAhmed, Ahmed AliElsayed, Mahmoud GamalNagy, MariaAli, Nouran YElahmady, MaryamKamel, Ahmed MAbd Elkodous, MahmoudMaallem, ImeneKaml, Maria B. ShNasser, NayeraNouh, Ahmed AlaaEldinSafwat, Fatma MAlshal, Mai MAhmed, Salma KNagib, TahaEl-sayed, Fatma MAlmahdi, ManalAdla, YahiaElNashar, Noha THussien, Aya MisbahSalih, Alaa SMahmoud, Somaya AbdulbasetMagdy, ShireenAhmed, Diana IHassan, Fayrouz Mohamed SaeedEdward, Nermin AMilad, Kirolos SaidHalasa, Shereen RArafa, Mohamed MKawamura, GoTan, Wai KianMatsuda, AtsunoriHegazy, Abdullah2021-11-172021-11-1727/09/2021https://doi.org/10.1515/ntrev-2021-0099http://repository.msa.edu.eg/xmlui/handle/123456789/4774ScopusGlobal overpopulation, industrial expansion, and urbanization have generated massive amounts of wastes. This is considered as a significant worldwide challenge that requires an urgent solution. Additionally, remarkable advances in the field of biomedicine have impacted the entire spectrum of healthcare and medicine. This has paved the way for further refining of the outcomes of biomedical strategies toward early detection and treatment of different diseases. Various nanomaterials (NMs) have been dedicated to different biomedical applications including drug delivery, vaccinations, imaging modalities, and biosensors. However, toxicity is still the main factor restricting their use. NMs recycled from different types of wastes present a pioneering approach to not only avoid hazardous effects on the environment, but to also implement circular economy practices, which are crucial to attain sustainable growth. Moreover, recycled NMs have been utilized as a safe, yet revolutionary alternative with outstanding potential for many biomedical applications. This review focuses on waste recycled NMs, their synthesis, properties, and their potential for multiple biomedical applications with special emphasis on their role in the early detection and control of multiple diseases. Their pivotal therapeutic actions as antimicrobial, anticancer, antioxidant nanodrugs, and vaccines will also be outlined. The ongoing advancements in the design of recycled NMs are expanding their diagnostic and therapeutic roles for diverse biomedical applications in the era of precision medicine. © 2021 Mohamed Abd Elkodous et al., published by De Gruyteren-USanticancer agentsantimicrobial activitybiomass wastesbiomedical applicationsrecycled nanomaterialsArticlehttps://doi.org/10.1515/ntrev-2021-0099