El-Masry, Rana MKadry, Hanan HTaher, Azza TAbou-Seri, Sahar M2022-05-122022-05-1222/04/2022https://doi.org/10.3390/molecules27092709http://repository.msa.edu.eg/xmlui/handle/123456789/4934ScopusThe bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharma- cophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design, synthesis, and the study of their potential activity towards a variety of diseases, including microbial and viral infections, cancer, diabetes, pain, and inflammation. This work is an up-to-date comparative study that identifies the differences between 1,3,4-thiadiazoles and 1,3,4-oxadiazoles concerning their methods of synthesis from different classes of starting compounds under various reaction conditions, as well as their biological activities and structure–activity relationship.en-US1,3,4-oxadiazole1,3,4-thiadiazoleBioisosteresBiological activitystructure–activity relationshipArticlehttps://doi.org/10.3390/molecules27092709