Farag A.G.A.Zytoon A.A.Habib M.S.Elnaidany N.F.Ibrahem R.A.L.Salman S.Mahfouz R.Z.Department of DermatologyAndrology and STDsFaculty of MedicineMenoufia UniversityShebin El-KomMenoufia Governorate23511Egypt; Department of RadiologyFaculty of MedicineEgypt; Department of Medical BiochemistryFaculty of MedicineEgypt; Public Health and Community MedicineFaculty of MedicineEgypt; Department of Clinical PathologyMenoufia UniversityShebin El-KomMenoufia GovernorateEgypt; Department of Clinical PharmacyFaculty of PharmacyModern Sciences and Arts University6th of October CityGiza GovernorateEgypt; Hematology and Oncology ResearchCleveland Clinic Lerner College of Medicine (CCLCM)Case Western UniversityClevelandOHUnited States2020-01-092020-01-09201816871537https://doi.org/10.1097/01.EWX.0000532719.31339.7cPubMed ID :https://t.ly/MXM7ZScopusBackground Mean platelet volume (MPV), may help to determine atherosclerosis threat. Cardiovascular disease is one of the common causes of morbidity and mortality in patients having psoriasis. Objective To examine MPV as a biomarker for subclinical atherosclerosis in psoriasis patients, compared with interleukin (IL)-1?, IL-6, and carotid intima media thickness (CIMT). Patients and methods Psoriatic patients (n=70) and age-matched and sex-matched healthy controls (n=60) were enrolled. Psoriasis Area and Severity Index score was used to assess psoriasis severity. For all enrolled participants; evaluation of MPV, IL-1?, and IL-6 serum levels, and measuring of CIMT were done. Results The mean values of MPV, IL-1, IL-6, and CIMT, all were significantly elevated in psoriatic patients than controls (P<0.05 for all). They were significantly correlated with each other (P<0.001), and with severity of psoriasis. Receiver operating characteristic curve analysis showed the possible validity of MPV for detection of subclinical atherosclerosis in psoriatic patients (sensitivity=90.9%, specificity=61.5%, accuracy=80%, area under the curve=0.82, P<0.001, 95% confidence interval=0.71-92) with 8.95 fl/ml as a cutoff value. Conclusion MPV is a good sensitive test for early prediction of atherosclerosis in psoriatic patients. We recommend a follow-up large scale study on psoriasis to examine the use of antiplatelets. � 2018 Egyptian Women's Dermatologic Society.Englishatherosclerosiscarotid intima media thicknesinterleukin-1interleukin-6mean platelet volumepredictive biomarkerpsoriasisbiological markerinterleukin 1alphainterleukin 6adultarterial wall thicknessArticleatherosclerosisclinical examinationcontrolled studydiagnostic accuracyfemalefollow uphumanmajor clinical studymalemean platelet volumemeasurementonset ageprognosisprotein blood levelpsoriasisPsoriasis Area and Severity Indexreceiver operating characteristicsensitivity and specificitysubclinical atherosclerosisArticlehttps://doi.org/10.1097/01.EWX.0000532719.31339.7cPubMed ID :