El-Refaei M.F.El-Naa M.M.Molecular Biology DepartmentGenetic Engineering and Biotechnology InstituteMenoufiya UniversityEgypt; Department of Pharmacology and ToxicologyFaculty of PharmacyOctober University for Modern Sciences and ArtsEgypt2020-01-252020-01-25201092797https://doi.org/10.1016/j.cbi.2010.04.019PubMed ID 20433813https://t.ly/w15JkScopusThis study aims at investigating the anti-tumor effect of caffeic acid phenethyl ester (CAPE) against animal carcinogenesis. In order to substantiate this fact implanted tumor Ehrlich carcinoma cells were assessed in vivo to Swiss mice strain. We found that administrating of CAPE (15. mg/kg S.C.) showed that the tumor volume decreased significantly by 51%. As a result, it improved animal chances of survival and they became healthier. An anti-angiogenic effect of CAPE in vivo was observed, as determined by a significant serum matrix metalloproteinase (MMP-9) reduction (142.1. ng/ml), activation of endostatin serum level (1.9. ng/ml), as well as DNA fragmentation in tumor treated mice when compared with untreated ones. Conclusion: CAPE has a significant inhibitory effect on tumor in vivo. This inhibition may be related to its angiostatic and apoptotic effects. It also reduced angiogenic factors which may shift the equilibrium to the angiostatic effect of CAPE. These findings provide the possibility for the future use of CAPE as tumor therapy in human clinical trials. � 2010 Elsevier Ireland Ltd.EnglishAnti-angiogenesisAnti-tumorApoptosisDNA fragmentationcaffeic acid phenethyl esterendostatingelatinase Banimal cellanimal experimentanimal modelantiangiogenic activityantineoplastic activityapoptosisarticlecancer inhibitioncancer survivalcontrolled studyDNA fragmentationEhrlich ascites tumorfemalein vivo studymousenonhumanAnimalsAntineoplastic AgentsApoptosisCaffeic AcidsCarcinoma, Ehrlich TumorDNA FragmentationEndostatinsFemaleHumansMatrix Metalloproteinase 9MiceNeovascularization, PathologicPhenylethyl AlcoholAnimaliaMusInhibitory effect of caffeic acid phenethyl ester on mice bearing tumor involving angiostatic and apoptotic activitiesArticlehttps://doi.org/10.1016/j.cbi.2010.04.019PubMed ID 20433813