Mohareb R.M.El-Arab E.E.El-Sharkawy K.A.Faculty of PharmacyOctober University for Modern Sciences and ArtsElwahaat RoadOctober CityEgypt; Faulty of ScienceChemistry DepartmentCairo UniversityEgypt; National Organization of Drug Control and Research (NODCAR)P.O. 29CairoEgypt2020-01-252020-01-252009368709https://doi.org/10.3797/scipharm.0901-20https://t.ly/0Mge3ScopusThe hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2-10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs. � Mohareb et al.; licensee �sterreichische Apotheker-Verlagsgesellschaft m. b. H.EnglishAntimicrobialPyridineThiazoleThiophene2 cyano n '(1 furan 2 ylethylidene) 3 (4 methoxyphenyl)prop 2 enehydrazide2 cyano n (1 furan 2 ylethylidene) 3 phenylprop 2 enehydrazide2 cyano n' (1 furan 2 ylethylidene) 2 (phenylhydrazono)acetohydrazide2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methoxyphenyl)hydrazono]acetohydrazide2 cyano n' (1 furan 2 ylethylidene) 2 [(4 methylphenyl)hydrazono]acetohydrazide3 (4 chlorophenyl) 2 cyano n' (1 furan 2 ylethylidene)prop 2 enehydrazide3 amino n' (1 furan 2 ylethylidene) 4,5,6,7 tetrahydro 1 benzothiophene 2 carbohydrazide3,5 diamino 4 cyano n' (1 furan 2 ylethylidene)thiophene 2 carbohydrazide4 amino n' (1 furan 2 ylethylidene) 3 phenyl 2 thioxo 2,3 dihydro 1,3 thiazole 5 carbohydrazide4,6 diamino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 1,2 dihydropyridine 3 carbonitrile6 amino 1 [(1 furan 2 ylethylidene)amino] 2 oxo 4 phenyl 1,2 dihydropyridine 3,5 dicarbonitrileacetic acid derivativeampicillinantiinfective agentcoumarin derivativecycloheximideethyl 2 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 4 phenyl 1,6 dihydropyridine 3 carboxylateethyl 2,4 diamino 5 [[2 (1 furan 2 ylethylidene)hydrazino]carbonyl]thiophene 3 carboxylic acidethyl 4 amino 5 cyano 1 [(1 furan 2 ylethylidene)amino] 6 oxo 1,6 dihydropyridine 2 carboxylic acidfuran derivativehydrazide derivativehydrazone derivativen' (1 furan 2 ylethylidene) 2 oxo 2h chromene 3 carbohydrazidepyridine derivativethiazole derivativethiophene derivativeunclassified drugantimicrobial activityarticleBacillus cereusBacillus subtilisCaenorhabditis eleganschemical reactioncontrolled studydrug synthesisEscherichia coliminimum inhibitory concentrationnonhumanArticlehttps://doi.org/10.3797/scipharm.0901-20