Abd El-Halim, Hanan F.Mohamed, Gehad G.Khalil, Eman A. M.2019-12-232019-12-232017Cited References in Web of Science Core Collection: 560022-2860https://doi.org/https://www.sciencedirect.com/science/article/abs/pii/S0022286017307032Accession Number: WOS:000406985800021A series of mixed ligand complexes were prepared from the Schiff base (L-1) as a primary ligand, prepared by condensation of oxamide and furan-2-carbaldehyde, and 1,10-phenanthroline (1,10-phen) as a secondary ligand. The Schiff base ligand and its mixed ligand chelates were characterized based on elemental analysis, IR, H-1 NMR, thermal analysis, UV-Visible, mass, molar conductance, magnetic moment. X-ray diffraction, solid reflectance and ESR also have been studied. The mixed ligand complexes were found to have the formulae of [M(L-1) (1,10-phen)]Cl-m.nH(2)O (M = Cr(III) and Fe(III) (m = 3) (n = 0); M = Mn(II), Cu(II) and Cd(II) (m = 2) (n = 0); and M = Co(II) (m = 2) (n = 1), Ni(II) (m = 2) (n = 2) and Zn(II) (m = 2) (n = 3)) and that the geometrical structure of the complexes were octahedral. The parameters of thermodynamic using Coats-Redfern and Horowitz-Metzger equations were calculated. The synthesized Schiff base ligand, 1,10-phenanthroline ligand and Their mixed ligand complexes were also investigated for their antibacterial and antifungal activity against bacterial species (Gram-Ve bacteria: Pseudomonas aeruginosa and Escherichia coli) and (Gram + Ve bacteria: Bacillus subtilis and Streptococcus pneumonia) and fungi (Aspergillus fumigates and Candida albicans). The anticancer activity of the new compounds had been tested against breast (MFC7) and colon (HCT-116) cell lines. The results showed high activity for the synthesized compounds. (C) 2017 Elsevier B.V. All rights reserved.enUniversity of Antitumor agents; Biological activity; Mixed ligand complexes; Schiff bases; ThermodynamicsTRANSITION-METAL-COMPLEXES; COORDINATION BEHAVIOR; SPECTROSCOPIC CHARACTERIZATION; STRUCTURAL-CHARACTERIZATION; ANTIBACTERIAL ACTIVITY; ANTICANCER ACTIVITY; LOMEFLOXACIN DRUG; CRYSTAL-STRUCTURE; GLYCINE; CU(II)Articlehttps://doi.org/