Khalil, Merna Samir KamelAbdelhamid, Mohamed SalahYouseif, Nada Mohamed ZoheirAmin, Noran Magdy Abdelmenuim2024-06-092024-06-092022Faculty Of Pharmacy Graduation Project 2020 - 2022http://repository.msa.edu.eg/xmlui/handle/123456789/6059Cancer has been one of the main causes of mortality over the past few decades. 1,3,4- Thiadiazole is a nitrogenous heterocyclic five-membered ring with several medicinal applications, it is also known to possess potent anticancer activity through different mechanisms of action allowing it to be used as a starting compound for designing anticancer drugs. In this study, some novel 1,3,4-thiadiazole derivatives bearing thiazole ring were synthesized and screened for cytotoxic activity and selectivity against breast (MCF-7), liver (HepG2), and normal (Vero) cell lines using 5-Fluorouracil as a positive control. The tested compounds showed promising activity with high selectivity indicesen-USOctober University For Modern Sciences and ArtsMSAOctober University For Modern Sciences and Arts MSAجامعة اكتوبر للعلوم الحديثة والادابcancerthiadiazol derivativesOther