Belwal T.Ezzat, Shahira MRastrelli L.Bhatt I.D.Daglia M.Baldi A.Devkota H.P.Orhan I.E.Patra J.K.Das G.Anandharamakrishnan C.Gomez-Gomez L.Nabavi S.F.Nabavi S.M.Atanasov A.G.G. B. Pant National Institute of Himalayan Environment and Sustainable DevelopmentKosi-KatarmalAlmoraUttarakhand 263643India; Department of PharmacognosyFaculty of PharmacyCairo UniversityGizaEgypt; Department of PharmacognosyFaculty of PharmacyOctober University for Modern Science and Arts (MSA)6th October12566Egypt; Dipartimento diFarmaciaUniversity of Salernovia Giovanni Paolo IIFisciano84084Italy; Department of Drug SciencesMedicinal Chemistry and Pharmaceutical Technology SectionPavia UniversityVialeTaramelli 12Pavia27100Italy; School of PharmacyKumamoto University5-1 Oe-honmachiChuo kuKumamoto 862-0973Japan; Program for Leading Graduate SchoolsHealth life Science: Interdisciplinary and Glocal Oriented (HIGO) ProgramKumamoto UniversityKumamotoJapan; Department of PharmacognosyFaculty of PharmacyGazi UniversityAnkara06330Turkey; Research Institute of Biotechnology & Medical Converged ScienceDongguk University-SeoulGoyang-si10326South Korea; Computational Modelling and Nanoscale Processing UnitIndian Institute of Food Processing TechnologyThanjavurTamil Nadu 613005India; Facultad de FarmaciaUniversidad de Dastilla-La ManchaCampus Universitario S/nAlbacete02071Spain; Applied Biotechnology Research CenterBaqiyatallah University of Medical SciencesTehranIran; Molecular Biology DepartmentInstitute of Genetics and Animal Breeding of the Polish Academy of SciencesJastrzebiecPoland; Department of PharmacognosyUniversity of ViennaAlthanstrasse14Vienna1090Austria2020-01-092020-01-092018https://doi.org/10.1016/j.trac.2017.12.018PubMed ID :https://t.ly/dOgZMScopusMSA Google ScholarPlant extracts have been long used by the traditional healers for providing health benefits and are nowadays suitable ingredient for the production of formulated health products and nutraceuticals. Traditional methods of extraction such as maceration, percolation, digestion, and preparation of decoctions and infusions are now been replaced by advanced extraction methods for increased extraction efficiency and selectivity of bioactive compounds to meet up the increasing market demand. Advanced techniques use different ways for extraction such as microwaves, ultrasound waves, supercritical fluids, enzymes, pressurized liquids, electric field, etc. These innovative extraction techniques, afford final extracts selectively rich in compounds of interest without formation of artifacts, and are often simple, fast, environment friendly and fully automated compared to existing extraction method. The present review is focused on the recent trends on the extraction of different bioactive chemical constituents depending on the nature of sample matrices and their chemical classes including anthocyanins, flavonoids, polyphenols, alkaloids, oils, etc. In addition, we review the strategies for designing extraction, selection of most suitable extraction methods, and trends of extraction methods for botanicals. Recent progress on the research based on these advanced methods of extractions and their industrial importance are also discussed in detail. � 2017 Elsevier B.V.Advanced extraction techniquesBioactive compoundsGreen extractionMicrowave assisted extraction (MAE)Plant matricesPressurized liquid extraction (PLE)Supercritical fluid extraction (SFE)Ultrasonic assisted extraction (UAE)AnthocyaninsEffluent treatmentElectric fieldsIndustrial researchPlant extractsSolventsSupercritical fluid extractionSupercritical fluidsBioactive compoundsExtraction techniquesGreen extractionsMicrowave-assisted extractionPressurized liquid extractionSupercritical fluid extraction (SFE)Ultrasonic-assisted extractionsExtractionalkaloidanthocyanincarotenoidflavonoidplant extractpolyphenolpolysaccharidesaponinsolventvegetable oilbarkBox Behnken designcentral composite designenzyme assisted extractionextractionflowerfruitmicrowave assisted extractionmoisturenonhumanparticle sizeplantplant leafplant rootplant seedpressurized liquid extractionpriority journalpulsed electric fieldpulsed electric field assisted extractionresponse surface methodReviewrhizomesupercritical fluid extractionultrasonic assisted extractionhttps://doi.org/10.1016/j.trac.2017.12.018PubMed ID :