El-Sharkawy K.A.Organic Chemistry DepartmentFaculty of PharmacyOctober University for Modern Sciences and Arts (M.S.A)El-Wahat road6 October CityEgypt2020-01-252020-01-2520119751459https://doi.org/https://t.ly/W5eP7ScopusThe synthesis of different 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid methyl esters (3-11) by coupling 2-substituted-3-acetyl-thiazolidine-4-carboxylic acid with amino acid methyl ester hydrochloride, corresponding amino acid hydrazides (12-20) via hydrazinolysis using hydrazine hydrate and 2-substituted- 3-acetyl-thiazolidine-4-carbonyl-N-benzylidine glycine hydrazone derivatives (21-26) were prepared via the condensation reaction of 2-substituted-3-acetyl-thiazolidine-4-carbonyl amino acid hydrazides with benzaldehyde and 4-chlorobenzaldehyde. The structures of the synthesized compounds were established by IR, 1H-NMR and MS data and elemental analysis results. The synthesized compounds were tested against different types of microorganism included gram-positive, gram-negative microorganisms Bacillius subtilis, Bacillus pumilus, Pesudomonas aeruginosa and Escherichia coli and the fungi Candida utilis. Some of the synthesized compounds were found to possess antimicrobial activities towards different type of microorganisms.EnglishAmino acid derivativesAntimicrobialThiazolidine2 acetyl 2 methylthiazolidine 4 carbonyl glycine methyl ester2 substituted 3 acetylthiazolidine 4 carbonyl amino methyl ester2 substituted 3 acetylthiazolidine 4 carboxylic acid derivative2 substituted thiazolidine 4 carboxylic acid derivative3 acetyl 2 methylthiazolidine 4 carbonyl alanine hydrazide3 acetyl 2 methylthiazolidine 4 carbonyl alanine methyl ester3 acetyl 2 methylthiazolidine 4 carbonyl glycine hydrazide3 acetyl 2 methylthiazolidine 4 carbonyl methionine hydrazide3 acetyl 2 methylthiazolidine 4 carbonyl methionine methyl ester3 acetyl 2 methylthiazolidine 4 carbonyl n 4 chlorobenzylidine glycine hydrazone3 acetyl 2 methylthiazolidine 4 carbonyl n benzylidine glycine hydrazone3 acetyl 2 phenylthiazolidine 4 carbonyl alanine hydrazide3 acetyl 2 phenylthiazolidine 4 carbonyl alanine methyl ester3 acetyl 2 phenylthiazolidine 4 carbonyl glycine hydrazide3 acetyl 2 phenylthiazolidine 4 carbonyl glycine methyl ester3 acetyl 2 phenylthiazolidine 4 carbonyl methionine hydrazide3 acetyl 2 phenylthiazolidine 4 carbonyl methionine methyl ester3 acetyl 2 phenylthiazolidine 4 carbonyl n 4' chlorobenzylidine glycine hydrazone3 acetyl 2 phenylthiazolidine 4 carbonyl n benzylidine glycine hydrazone3 acetyl 2,2 dimethylthiazolidine 4 carbonyl alanine hydrazide3 acetyl 2,2 dimethylthiazolidine 4 carbonyl alanine methyl ester3 acetyl 2,2 dimethylthiazolidine 4 carbonyl glycine hydrazide3 acetyl 2,2 dimethylthiazolidine 4 carbonyl glycine methyl ester3 acetyl 2,2 dimethylthiazolidine 4 carbonyl methionine hydrazide3 acetyl 2,2 dimethylthiazolidine 4 carbonyl methionine methyl ester3 acetyl 2,2 dimethylthiazolidine 4 carbonyl n 4' chlorobenzylidine glycine hydrazone3 acetyl 2,2 dimethylthiazolidine 4 carbonyl n benzylidine glycine hydrazoneamino acid derivativesulfadimidineunclassified drugunindexed drugantimicrobial activityarticleBacillus pumilusBacillus subtiliscontrolled studydrug structuredrug synthesisEscherichia coliinfrared spectroscopymass spectrometryminimum inhibitory concentrationnonhumanPichia jadiniiproton nuclear magnetic resonancePseudomonas aeruginosaArticlehttps://doi.org/