El-Beltagi H.S.Mohamed H.I.Safwat G.Gamal M.Megahed B.M.H.Faculty of AgricultureBiochemistry DepartmentCairo UniversityGizaCairoEgypt; College of Agriculture and Food SciencesAgricultural Biotechnology DepartmentKing Faisal UniversityAlhassaSaudi Arabia; Research Park (CURP)Cairo UniversityGizaCairoEgypt; Faculty of EducationDepartment of Biological and Geological scienceAin shams UniversityCairoEgypt; Faculty of BiotechnologyOctober University for Modern Science and Art (MSA)GizaEgypt2020-01-092020-01-0920193674223https://doi.org/10.1007/s10343-019-00456-8PubMedIDhttps://t.ly/PMP9lScopusPhysalis peruviana L. belongs to the family Solanaceae and is considered as plant used for treating various diseases. The protective mechanism of Physalis consists of the ability to scavenge reactive oxygen species (ROS) and to enhance the antioxidant system in the human body. The ethanolic extract of Physalis peruviana fruits contains valuable and active compounds such as carotenoids, phenols, flavonoids, tannin, alkaloids, vitamins C, B3 and B6. Therefore, Physalis peruviana extract has antioxidant and antimicrobial activity against gram-positive and gram-negative bacteria. Gram-positive Bacillus cereus demonstrated higher susceptibility than gram-negative Escherichia coli and Pseudomonas typhimureum. Also, the extract showed positive effect on the fungus used (Aspergillus niger and Candida albicans). In addition, high concentrations of Physalis peruviana ethanolic extract (800 g/ml) exhibited significant anticancer activity against lung (A549) cells but slight effect against colorectal adenocarcinoma (Caco-2) cells. 2019, Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature.EnglishOctober University for Modern Sciences and ArtsUniversity for Modern Sciences and ArtsMSA Universityجامعة أكتوبر للعلوم الحديثة والآدابAnticancer activityDPPHFlavonoidsPhenolsPhysalis peruvianaArticlehttps://doi.org/10.1007/s10343-019-00456-8PubMedID