Saleh N.A.Ezzat, Shahira MEl-Kashoury E.-S.A.Taha K.F.Medicinal Plants DepartmentNational Organization for Drug Control and ResearchPyramid Ave.6 Abou Hazem StreetCairoEgypt; Pharmacognosy DepartmentFaculty of PharmacyCairo UniversityKasr El-Ainy StreetCairo11562Egypt; Pharmacognosy DepartmentFaculty of PharmacyOctober University for Modern Science and Arts (ShamsaMonsefGhamooshiand Verdian-rizi)6th October City12566Egypt2020-01-092020-01-09201913004182https://doi.org/https://t.ly/VZZLMScopusMSA Google ScholarSpectrophotometric quantitative determination of polyphenols, flavonoids, alkaloids, sterols, and carbohydrates of the leaves, flowers and fruits of Tecoma x smithii Will. Wats. was performed, as well as the lipoidal matter (unsaponifiable compounds and fatty acids methyl esters) that were investigated using gas chromatography-mass spectrometry (GC-MS). Representative aromatic acids where estimated for the three parts using HPLC. Polyphenols and flavonoids were most concentrated in the 70% ethanol extract of the leaves. The investigation of the ethyl acetate fraction of the 70% ethanol extract of the leaves resulted in isolation and identification of Chrysoeriol (E1), Luteolin (E2), and Caffeic acid (E3). Two other compounds were also isolated from the n-butanol fraction: Chlorogenic acid (B1) and Rutin (B2). The ethanolic and aqueous extracts of the leaves were evaluated for their acute toxicity, anti-inflammatory, antipyretic, analgesic, and anti-hyperglycemic activities. Both extracts were regarded safe and could significantly reduce the blood glucose level in alloxan- diabetic rats and showed a comparable antipyretic and analgesic effect to the reference standards used in the study. � 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.EnglishOctober University for Modern Sciences and ArtsUniversity for Modern Sciences and ArtsMSA Universityجامعة أكتوبر للعلوم الحديثة والآدابAntidiabeticGallic acidGC-MSNonacosaneQuercetinSitosterol1 hexadecene1 hexadecyne1 nonadecene1 octadecene2 phenyl dodecane2 phenyl tridecane2 phenyl undecane3 phenyl dodecane3 phenyl tridecane3 phenyl undecane5 eicosene5 phenyl tridecane5 phenyl undecane6 phenyl tridecane6,10,14 trimethyl 2 pentadecanone6,6 dimethyl cyclooct 4 enoneantidiabetic agentantiinflammatory agentantipyretic analgesic agentcyclohexadecaneheptadecaneindometacinmetforminneophytadienenonadecaneparacetamolplant extractstearic acidtecoma x smithii hort extractunclassified drugunindexed druganimal experimentantidiabetic activityantiinflammatory activityArticlechemical analysiscomparative studycontrolled studydrug determinationdrug identificationdrug potencydrug screeningflowerfruithigh performance liquid chromatographylimit of quantitationmass fragmentographynonhumanplant leafquantitative analysisratTecomaTecoma x smithii hortArticlehttps://doi.org/