Mohareb, Rafat M.Fleita, Daisy H.Sakka, Ola K.2020-01-042020-01-042011Cited References in Web of Science Core Collection: 170793-0283https://doi.org/10.1515/HC.2011.017https://cutt.ly/Druh4iYAccession Number: WOS:000297078100006The condensation reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) with 2-acetyl-furan (2) afforded 2-amino-4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile (3). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4, 5d and 12 showed high inhibitory effects.enantitumor activityfuranpyrazolequinolinethiopheneArticlehttps://doi.org/10.1515/HC.2011.017