Abdel Rahman M.F.Hashad I.M.Abou-Aisha K.Abdel Maksoud S.M.Gad M.Z.Biochemistry DepartmentFaculty of PharmacyOctober University for Modern Sciences and Arts (MSA)CairoEgypt; Clinical Biochemistry UnitFaculty of Pharmacy & BiotechnologyGerman University in CairoCairoEgypt2020-01-092020-01-0920173051870https://doi.org/10.1111/1440-1681.12684PubMed ID 27761928https://t.ly/DXE6lScopusThe aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83�0.7�pg/mL) was significantly higher than controls (7.26�0.2�pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls. � 2016 John Wiley & Sons Australia, LtdEnglishacute myocardial infarctionEgyptianendothelinpolymorphismendothelinendothelin 1endothelin 1acute heart infarctionadultcontrolled studyEgyptianfemalegene frequencygenotypehumanincidenceLettermajor clinical studymaleprotein blood levelsingle nucleotide polymorphismbloodEgyptgenetic linkagegeneticsmiddle agedMyocardial Infarctionsingle nucleotide polymorphismAdultEgyptEndothelin-1FemaleGenetic LinkageHumansMaleMiddle AgedMyocardial InfarctionPolymorphism, Single NucleotideLetterhttps://doi.org/10.1111/1440-1681.12684PubMed ID 27761928