Gheith M.E.Khairy M.A.National Institute of Laser Enhanced Sciences (N.I.L.E.S)Cairo UniversityCairoEgypt; Faculty of Oral and Dental MedicineOctober University for Modern Science and ArtsCairoEgypt2020-01-092020-01-0920149.78E+1216057422https://doi.org/10.1117/12.2036100PubMed ID :https://t.ly/OXXYAScopusSimvastatin is a cholesterol lowering drug which proved effective on promoting bone healing. Recently low level laser therapy (LLLT) proved its effect as a biostimulator promoting bone regeneration. This study aims to compare the effect of both Simvastatin versus low level laser on bone healing in surgically created bone defects in rabbit’s tibia. Material and methods: The study included 12 New Zealand white rabbits. Three successive 3mm defects were created in rabbits tibia first defect was left as control, second defect was filled with Simvastatin while the third defect was acted on with Low Level Laser (optical fiber 320micrometer). Rabbits were sacrificed after 48 hours, 1 week and 2 weeks intervals. Histopathology was conducted on the three defects Results: The histopathologic studies showed that the bony defects treated with the Low Level Laser showed superior healing patterns and bone regeneration than those treated with Simvastatin. While the control defect showed the least healing pattern.EnglishBony defectDiode laser 980 nmSimvastatinBoneDentistryLaser surgeryOptical fibersBone regenerationBony defectsCholesterol loweringControl defectsLow level laserLow level laser therapyNew Zealand White rabbitSimvastatinDefectsConference Paperhttps://doi.org/10.1117/12.2036100PubMed ID :