Motawi T.M.K.Shaker O.G.El-Sawalhi M.M.Abdel-Nasser Z.M.Biochemistry DepartmentFaculty of PharmacyCairo UniversityCairoEgypt; Medical Biochemistry and Molecular Biology DepartmentFaculty of MedicineCairo UniversityCairoEgypt; Biochemistry DepartmentFaculty of PharmacyModern Sciences and Arts UniversityCairoEgypt2020-01-092020-01-0920148312796https://doi.org/10.1139/gen-2014-0022PubMed ID 25120107https://t.ly/VZKqeScopusDiabetes mellitus is one of the main threats to human health in the 21st century. Visfatin/Nampt and resistin are novel adipokines that have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) complication. Several genetic studies have shown inconsistent results regarding association of visfatin/Nampt gene (NAMPT) and resistin gene (RETN) polymorphisms with T2DM and CVD complications. Here, we investigate whether NAMPT -948G/T and RETN -420C/G polymorphisms are associated with T2DM, its CVD complications, and serum adipokines levels in 90 Egyptian diabetic patients (44 without CVD and 46 with CVD) along with 60 healthy control subjects. Higher frequencies of NAMPT -948G/G and RETN -420G/G were observed among T2DM patients compared with controls. Furthermore, the frequencies of these genotypes were significantly higher in T2DM patients with CVD than those without CVD. Both NAMPT -948G/G and RETN -420G/G genotypes and G alleles were significantly associated with T2DM and CVD in Egyptian diabetic patients. Moreover, serum visfatin/Nampt and resistin levels were markedly elevated in T2DM patients, with the highest values observed in G/G genotypes among T2DM patients with CVD. In addition, positive correlations were observed between plasma adipokines levels and CVD risk factors. In conclusion, our data suggests that genetic variations in NAMPT -948G/T and RETN -420C/G may contribute to the disposition for T2DM and its CVD complications in Egyptian patients. However, further studies with greater sample size should be performed to verify these results. 2014 Published by NRC Research Press.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversityCardiovascular diseaseNAMPT -948 G/TPolymorphismsRETN -420 C/GType 2 diabetes mellituscytokinenicotinamide phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanresistinRETN protein, humanadultbloodcardiovascular diseaseCaucasiancomplicationdisease predispositionEgyptfemalegenetic associationgeneticshumanmalemiddle agednon insulin dependent diabetes mellitussingle nucleotide polymorphismAdultCardiovascular DiseasesCytokinesDiabetes Mellitus, Type 2Disease SusceptibilityEgyptEuropean Continental Ancestry GroupFemaleGenetic Association StudiesHumansMaleMiddle AgedNicotinamide PhosphoribosyltransferasePolymorphism, Single NucleotideResistinArticlehttps://doi.org/10.1139/gen-2014-0022PubMed ID 25120107