Sakr T.M.Ibrahim I.T.Abd-Alla W.H.Radioactive Isotopes and Generator DepartmentHot Labs CenterAtomic Energy AuthorityP.O. 13759CairoEgypt; Pharmaceutical Chemistry DepartmentFaculty of PharmacyOctober University of Modern Sciences and Arts (MSA)GizaEgypt; Labelled Compound DepartmentHot Labs CenterAtomic Energy AuthorityP.O. 13759CairoEgypt; Department of Pharmaceutical ChemistryFaculty of PharmacyMisr University for Science & TechnologyP.O. 776th of OctoberEgypt2020-01-092020-01-0920182365731https://doi.org/10.1007/s10967-018-5770-zPubMed ID :https://t.ly/MXMOdScopusMSA Google ScholarAbstract: The aim of the presented study is to investigate a new promising radiopharmaceutical tracer able to visualize and differentiate inflammation versus infection in early stages. Radioiodinated tenoxicam (125I-tenoxicam) was prepared and its radiochemical yield and in vitro stability were assayed. The biodistribution studies were conducted on two different mice models: sterile inflammation and bacterial infection mice models. 125I-tenoxicam showed high T/NT accumulation in the inflammatory tissues revealing high selectivity to the inflammatory tissues in contrast to infection bearing mice. The docking study using CDOCKER protocol for tenoxicam and radioiodinated tenoxicam with COX enzymes was performed to confirm that radioiodinated tenoxicam still retaining COX enzymes selectivity. � 2018, Akad�miai Kiad�, Budapest, Hungary.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversityCyclooxygensase enzymeImagingInflammationMolecular dockingRadioiodinationTenoxicamcelecoxibibuprofeniodine 125tenoxicamtosylchloramide sodiumanimal experimentanimal modelanimal tissueArticlebacterial infectionbinding affinitybinding siteconcentration (parameters)controlled studydrug distributiondrug stabilitydrug structurehydrogen bondin vitro studyinflammatory diseasemolecular dockingmolecular interactionmolecular modelmousemouse modelnonhumanpH measurementpreclinical studyradioactivityradiochemistryradioiodinationreaction timeArticlehttps://doi.org/10.1007/s10967-018-5770-zPubMed ID :