Dkhil M.A.Al-Quraishy S.Diab M.M.S.Othman M.S.Aref A.M.Moneim A.E.A.Department of ZoologyCollege of ScienceKing Saud UniversityRiyadhSaudi Arabia; Department of Zoology and EntomologyFaculty of ScienceHelwan UniversityCairoEgypt; Department of Molecular Drug EvaluationNational Organization for Drug Control and Research (NODCAR)GizaEgypt; Department of Biochemistry and Molecular BiologyFaculty of BiotechnologyModern Sciences and Arts (MSA)GizaEgypt; Department of Biological ScienceFaculty of DentistryModern Sciences and Arts University (MSA)GizaEgypt; Department of Biochemistry and Molecular BiologyAsturias Institute of BiotechnologyUniversity of OviedoOviedoSpain2020-01-092020-01-0920142786915https://doi.org/10.1016/j.fct.2014.09.013PubMedID25265456https://t.ly/OXNWJScopusMSA Google ScholarThis study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5mg/kg bwt/day) was intraperitoneally injected for 5 days, and methanolic extract of physalis (MEPh) was pre-administered to a group of Cd-treated rats by an oral administration at a daily dose of 200mg/kg bwt for 5 days. The findings revealed that CdCl2 injection induced significant decreases in kidney weight and kidney index. Cadmium intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. The pre-administration of MEPh alleviated hepatorenal toxicity in Cd-treated rats. Physalis was noted to play a good hepatorenal protective role, reducing lipid peroxidation, nitric oxide, and enhancing enzymatic activities and non-enzymatic antioxidant molecule, glutathione, in hepatic and renal tissues of Cd-treated rats. Moreover, physalis treatment was able to reverse the histopathological changes in liver and kidney tissues and also increased the expression of Bcl-2 protein in liver and kidney of rats. Overall, the results showed that MEPh can induce antioxidant and anti-apoptotic effects and also exerts beneficial effects for the treatment of Cd-induced hepatorenal toxicity. � 2014 Elsevier Ltd.EnglishCadmiumKidneyLiverOxidative stressPhysalis peruviana LRatsbilirubincadmiumcadmium chloridecreatinineglutathionelipidliver enzymemethanolnitric oxidePhysalis peruviana extractplant extractprotein bcl 2unclassified drugureauric acidcadmium chlorideplant extractadultanimal cellanimal experimentanimal modelanimal tissueantioxidant activityapoptosisArticlebilirubin blood levelbody weightcontrolled studycreatinine blood levelenzyme activityfruithistopathologykidney masslipid peroxidationliver protectionliver toxicitymalenephrotoxicitynonhumanPhysalisPhysalis peruvianaprotein expressionrandomized controlled trialratrenal protectionSolanaceaeurea blood leveluric acid blood levelAcute Kidney Injuryanimalantagonists and inhibitorschemically induceddrug effectsDrug-Induced Liver Injuryfruitkidneyliveroxidative stresspathologyPhysalisphytotherapyproceduresWistar ratPhysalis peruvianaRattusAcute Kidney InjuryAnimalsCadmium ChlorideDrug-Induced Liver InjuryFruitKidneyLiverMaleOxidative StressPhysalisPhytotherapyPlant ExtractsRatsRats, WistarArticlehttps://doi.org/10.1016/j.fct.2014.09.013PubMedID25265456