Masoud, Khaled Abd-Elmonem SayedFarg, Mohamed Sherif Mohamed Salah EldinEl-Batawy, Osama Ibrahim Abd El-SalamAbd-El-Lateef, Shereef Samy2020-09-052020-09-052019-072320-5407http://repository.msa.edu.eg/xmlui/handle/123456789/3753Milk or milk component-based drinks seem to possess many of the biological and physical properties desired for a saliva substitute. Milk contains two primary sources of protein, the caseins and whey. Alpha- Lactalbumin (α-LA) is one of the main proteins found in human and bovine milk whey. Glycomacropeptide is a major component of casein protein .α-La with antimicrobial properties have been reported as α-La yielded bactericidal peptides. Both demonstrate a number of biological activities in medicine not only as milk protein but also as natural antibacterial. Aim of the study: To examine the antibacterial activities of milk proteins glycomacropeptide and alpha lactalbumin compared with chlorhexidine and their effect on Mutans streptococci count in human dental plaque samples from children. Materials and methods: Twenty children patient were sampled as follow six dental plaque samples were taken from each child from the buccal surface of first permanent molars , by sterile dental excavator and stored in Epindorff tube, then divided into six groups (Control group, Chlorhexidine group, Alpha lactalbumin1% (αLA1%), Alphalactalbumin2%(αLA2%,Casienglycomacropeptide1%(GMP1%), Casienglycomacropeptide 2% (GMP 2%)) then Mutans Streptococci in the plaque samples of tested children were evaluated using selective media for mutans Streptococci. Results: GMP 2% was the highest reduction followed GMP 1%, αLA 2% and αLA 1%.Conclusion: Alpha lactalbumin and Casienglycomacropeptide had antibacterial effect on Mutans Streptococci preset in dental plaque in children.en-USAlphalactalbumin.CasienglycomacropeptideCaseinMilk wheyPlaqueChlorhexidineArticle