Srivastava, SwatiAlharbi, Hanan MAlharbi, Afnan SSoliman, MaiEldwakhly, ElzahraaAbdelhafeez, Manal M2022-11-222022-11-222022-10https:// doi.org/10.3390/jpm12111784http://repository.msa.edu.eg/xmlui/handle/123456789/5252Various endodontic interventions often lead to iatrogenic damage to the inferior alve- olar nerve present in the inferior alveolar canal (IAC). The purpose of the present study was to analyze the relationships of IAC with the root apices of mandibular teeth and with the mandibu- lar cortical plates. Materials: 116 cone beam computed tomography (CBCT) scans were exam- ined and the shortest distance of IAC with the root apices of mandibular canines, premolars and molars, and with cortical plates was analyzed. The data were statistically analyzed using SPSS. Results: The shortest mean distance between IAC and lingual cortical plate (LCP) was found in the third molar area, and between IAC and buccal cortical plate (BCP) in the second premolar area. A high incidence of 60% direct communication (DC) was present in mandibular second mo- lars; 38% in mandibular third molars; 13% in mandibular second premolars; 12% in mandibular first molars; and 1% in mandibular first premolars. Conclusion: Anteriorly, IAC was found to be significantly present in close approximation to the roots of mandibular canines. Posteriorly, IAC was found to be in significant proximity to the distal roots of mandibular second molars.en-UScone beam computed tomographycortical platesendodontic mishapsiatrogenic errorinferior alveolar canal; paresthesia; proximity; root apexinferior alveolar nervemandibular teethneuropathyover-instrumentationArticlehttps:// doi.org/10.3390/jpm12111784