El Tanbouly N.El Sayed A.M.Ali Z.Y.Abdel Wahab S.El Gayed S.H.Ezzat, Shahira MEl Senousy A.S.Choucry M.A.Abdel-Sattar E.Department of PharmacognosyCollege of PharmacyCairo UniversityCairo11562Egypt; Department of BiochemistryNational Organization for Drug Control and ResearchGiza12553Egypt; Department of PharmacognosyCollege of PharmacyOctober University for Modern Sciences and Arts6th of October12566Egypt2020-01-092020-01-0920171741427Xhttps://doi.org/10.1155/2017/6405789PubMed ID :https://t.ly/EXwYjScopusMSA Google ScholarFlaxseed (Linum usitatissimum L.) is a multipurpose crop with health promoting potential. This study was undertaken to investigate the fatty acid profile and yield of fixed oil of six Egyptian flaxseed cultivars. The selected cultivars with the highest content of polyunsaturated fatty acids (PUFAs) (G9 and G10) were assessed for their antidepressant-like effect in rat model of postpartum depression (PPD) induced by hormone-simulated pregnancy followed by hormone withdrawal and compared to fluoxetine. As compared to control group, administration of G9 and G10 (270 mg/kg/day, p.o) for two weeks during the postpartum period can alleviate anxiety and depressive-like behaviors and biochemical changes in PPD-induced rats. This was confirmed by evaluation of anxiety-like behaviors (elevated plus maze, open field test, and forced swim test tests), in addition to biochemical analysis (brain monoamine oxidase-A, corticosterone level, proinflammatory cytokines, and hippocampal redox state). In conclusion, flaxseed oil of Egyptian cultivars G9 and G10 exhibited significant antidepressant-like effect in rat model of PPD without affecting locomotor activity. At the treatment doses, the antidepressant-like activity of Giza 9 oil is comparable to fluoxetine. � 2017 Nebal El Tanbouly et al.Englishamine oxidase (flavin containing) isoenzyme Aantidepressant agentcorticosteroneestradiol benzoatefluoxetineinterleukin 1betainterleukin 6linoleic acid ethyl esterlinolenic acidlinseed oiloleic acidoleic acid ethyl esteromega 3 fatty acidpalmitic acid ethyl esterpalmitic acid methyl esterprogesteronestearic acidtumor necrosis factoradultanimal experimentanimal modelantidepressant activityanxietyArticlebiochemical analysisbrain levelcontrolled studycorticosterone blood levelcultivarelevated plus maze testfemaleforced swim testnonhumanopen field testoxidation reduction statepostnatal depressionpregnancypuerperiumratArticlehttps://doi.org/10.1155/2017/6405789PubMed ID :