Hesham, AhmedSayed, HudaSalah, MarthaIbrahim, Mohamed2019-10-122019-10-122019Copyright © 2019 MSA University. All Rights Reserved.https://t.ly/g7g32Obesity is a serious condition in which body fats are excessively accumulate in the body and associated with several comorbidities like diabetes mellitus, cardiovascular diseases, and osteoarthritis. Moringa olifera is a traditional herbal medicine for treatment of conditions like arthritis, constipation, hypertension. The present study aimed to evaluate the anti-obesity and antihypercholesterolemic effect of the aqueous extract of Moringa olifera herbal teas as Moringa olifera alone and in combination with lemon and Mentha in a high fat diet induced obesity in rats. Adult male rats were completely randomized in ten groups each compromising six rats. The first group was kept on the normal rodent chow for three months but the rest of groups were kept on a high fat diet for two months. Group number 2 represent obese group, group number 3 was assigned as high fat diet group (HFD), group number 4 represent standard simvastatin treated group (SD) and from group 5 to 10 treated with Moringa olifera aqueous extract, these groups received medicine in different doses and preparations. mRNA expression of FAS was significantly high in HFD group compared to control and significantly decreased in all treated groups. Moringa lemon (ML) 400mg showed prominent effect compared to simvastatin groups. Also, mRNA expression of PPAR alpha was significantly reduced in HFD compared to control and significantly increased in all treated groups. In conclusion, study provides evidence that the aqueous extracts of Moringa olifera and its combinations have antiobesity effect.enOctober University for Modern Sciences and ArtsUniversity of Modern Sciences and ArtsMSA Universityجامعة أكتوبر للعلوم الحديثة والآدابBiochemistryMoringa OliferaOther