Attal, RomainBakkar, AshrafBouillaud, FredericDevin, AnneHenry, MarcPonti´e, MaximeRadman, MiroslavSchwartz, Laurent2023-12-202023-12-202023-11https://doi.org/10.1016/j.arres.2023.100087http://repository.msa.edu.eg/xmlui/handle/123456789/5782Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications.en05.70.Ln; 87.19.Xj; Cancer metabolism; Glutamine; Methylene blue; Non-equilibrium thermodynamics; Warburg effectArticlehttps://doi.org/10.1016/j.arres.2023.100087