Sakr T.M.Nawar M.F.Fasih T.W.El-Bayoumy S.Abd El-Rehim H.A.Radioactive Isotopes and Generators Dept.Hot Labs. CenterAtomic Energy AuthorityCairo13759Egypt; Pharmaceutical Chemistry DepartmentFaculty of PharmacyOctober University of Modern Sciences and Arts (MSA)GizaEgypt; National Center for Radiation Research and TechnologyAtomic Energy AuthorityCairoEgypt2020-01-092020-01-0920179698043https://doi.org/10.1016/j.apradiso.2017.08.012PubMed ID 28822270https://t.ly/8pJY1ScopusMSA Google ScholarNanostructured materials attracted considerable attention because of its high surface area to volume ratio resulting from their nano-scale dimensions. This class of sorbents is expected to have a potential impact on enhancement the efficacy of radioisotope generators for diagnostic and therapeutic applications in nuclear medicine. This review provides a summary on the importance of nanostructured materials as effective sorbents for the development of clinical-scale radioisotope generators and outlining the assessment of recent developments, key challenges and promising access to the near future. � 2017 Elsevier LtdEnglish188W/188Re generators68Ge/68Ga generator99Mo/99Tc generatorsNano sorbentsNanotechnologyRadioisotope generatorsRadiopharmaceuticalsDiagnosisInertial confinement fusionNanostructured materialsNuclear medicineRadioisotopesHigh surface areaNano scalePotential impactsRadioisotope generatorsRadiopharmaceuticalsTherapeutic ApplicationVolume ratio^68Ge/^68Ga generatorNanotechnologycesium 137gallium 68indium 113mmolybdenum 99nanomaterialradioisotoperhenium 188sorbenttechnetium 99muranium 235chemical procedurescolumn chromatographynanotechnologyprecipitationpriority journalradioactivityReviewsolvent extractionReviewhttps://doi.org/10.1016/j.apradiso.2017.08.012PubMed ID 28822270